This is a project simulation of a penicillin binding protein (PBP), which is a kind of bacterial protein that is targeted by many commonly used antibiotics. Some antibiotic resistant bacteria, however, produce class A beta-lactamases, which are proteins that break down these antibiotics. Class A beta-lactamases are thought to have evolved from the PBP we are simulating here. For this project, we are interested in identifying the functionally relevant motions of beta-lacatamases by determining which motions have been conserved over time and which have arose from gaining a new function.
List of Contributors
This project is managed by Justin R. Porter at Washington University in St. Louis.
Justin is an MD/PhD student at Washington University School of Medicine in St. Louis in Greg Bowman's lab.
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