The DNA mismatch repair cascade is an essential process for ensuring that the transference of genetic information over the meiotic process is accurate. In the case that an incorrect nucleobase is added to the daughter strand of DNA during meiosis, DNA mismatch repair mechanisms exist to remove the error-containing DNA on the daughter strand so that the base pair match can be corrected.
Both inherited and epigenetic mutations in mismatch machinery can lead to hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome. A particular protein that may be affected by such mutations is MutLα.
In this project, we simulate wild type yeast MutLα to gain informtion about its conformation and dynamics in solution, how it binds to DNA, and how mutations affect these interactions. This information can be used to better understand DNA mismatch repair diseases and aid in the design of potential therapeutics.
List of Contributors
This project is managed by Dylan Novack at Temple University.
Dylan Novack is PhD student in the Voelz Lab at Temple University.
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