This project simulates several myosins found in the human body. Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell. We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure. Myosin was featured as the PDB Molecule of the Month in June 2001.
List of Contributors
This project is managed by Artur Meller at Washington University in St. Louis.
Artur is a Graduate Student at Washington University School of Medicine in St. Louis in Greg Bowman's lab.
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