Projects 16422

Cause: covid-19

This project simultaes SARS-CoV-2 (COVID-19 causing virus) Non-structural protein 15 (NSP15). It is referred to as an "endonuclease", however the exact role it plays in the viral lifecycle is unclear. It is unknown if the endonuclease behavior is important fo host-immune evasion (evading our immune system) or for viral replication (further infection). We know it is a hexameric protein. That is, 6 NSP15 molecules assemble together to form the functional complex.

This project is simulating the monomeric form, in the hope of finding cryptic druggable sites that have not been previously observed. These would be useful to target for drug design efforts.

This project is related to 16408, 16410, and 16430.

List of Contributors

This project is managed by Sukrit Singh at Washington University in St. Louis.

Sukrit Singh is a Biophysics PhD student in Greg Bowman's lab at Washington University in St. Louis.

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