This project simulates the NSP7 co-factor in the monomeric state from SARS-CoV-2! To replicate itself, the virus uses "polymerase" proteins that transcribe the viral genome after it infects a host cell (aka our cells). The known polymerase of the viruses utilizes 3 proteins, NSP7 and NSP8, and NSP12. This project simulates NSP7 in isolation. Our hope is to identify a potentially druggable site in this polymerase for drug dessign efforts. This project is related to p16434.
List of Contributors
This project is managed by Sukrit Singh at Washington University in St. Louis.
Sukrit Singh is a Biophysics PhD student in Greg Bowman's lab at Washington University in St. Louis.
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