This project simulates the non-structural-protein 13 (NSP13) Helicase of from the Middle Eastern Respiratory Virus (MERS) to study how it interacts with viral RNA. Helicases act on the viral genome, made of RNA, and are useful for the viral replication and transmission. This project hopes to study the helicase NSP13 and identify potential hidden druggable pockets. By comparing the SARS-CoV-2 version (simulated in p16419) to this MERS version of NSP13, we are hoping to understand what makes SARS-CoV-2 a much more infectious virus!
List of Contributors
This project is managed by Sukrit Singh at Washington University in St. Louis.
Sukrit Singh is a Biophysics PhD student in Greg Bowman's lab at Washington University in St. Louis.
Enter the project number: